Huibai Reagent: the function characteristic and absorption way of suppository

The chemical dictionary tells you the characteristics of the suppository and its absorption pathway. Suppository: a solid preparation with a shape of intraluminal delivery made from a suitable substrate. The suppository is solid at room temperature. After plugging into the cavity canal, the suppository can quickly soften melting or dissolve in the secretion at body temperature, and gradually release the drug to produce local or systemic effects. In the early stage, it was thought that the suppository could only act as a lubricant, astringent, antibacterial agent, insecticidal agent, local anesthetic and so on. Later, it was found that the suppository could exert systemic effects through rectum absorption drugs and avoid the first-pass effect of liver.

Suppository action characteristics
The characteristics of the suppository are:
(1) drugs were not damaged by pH or enzyme in gastrointestinal tract;
(2) avoid the irritation of drugs to gastric mucosa;
(3) the absorption of the middle and lower rectal vein can avoid the first-pass effect of the liver;
(4) it is suitable for patients who cannot or do not take oral administration;
(5) can be lubricated, antibacterial, insecticidal, astringent, analgesic, antipruritic and so on in the cavity;
It is suitable for drugs that are not suitable for oral administration.

Suppository absorption pathway
The main ways of drug absorption in rectal administration suppository are:
1 the drug enters the liver through the superior rectal vein and the portal vein, and then circulates into the human body by the liver.
2 the drug passes through the inferior rectal vein and the anal vein, and bypasses the liver through the internal iliac vein and enters the systemic circulation directly from the inferior vena cava.
3 the drug was absorbed through the rectal lymphatic system.

The material comes from the network.
For more information on biochemical reagents, check out Huibai Reagent's official website: http://www.hnhbsj.com
(all contents of this website are marked as "Huibai Reagent", copyright is owned by Huibai Reagent. Any media, website or individual shall not be reproduced without authorization, otherwise, legal liability will be investigated. Authorization to reprint should be marked "source: Huibai Reagent". This website indicates the source is other media content is reprinted, reprint only for the viewpoint sharing, the copyright belongs to the original author all, if has the infringement copyright, please contact us in time.